Your cam is too mild for 400 horsepower. I have a Comp Cams 282S with 570 lift and even it is probably a bit mild for 400 horsepower with my 4v Closed chamber heads, but any more cam and you start to run into vacuum problems and decreased low end torque.
A G tech estimates and ET's suggest my engine is putting out 325 at the rear wheels, but only a dyno will say for sure. Competition Cams says my combo should be getting around 500 flywheel horsepower. I think their numbers are high and the G tech are likely a little low, but really, numbers don't mean too much.
My car will do 0-60 in 5.6 consistently with 3.50 gears and a stick shift even though it weighs 3,900 lbs with a driver and gas in it. With 4,11 gears and an automatic with the right stall speed converter and it would be 5.0 flat I suspect.
I would not waste the time and money on 2V heads. If you need 4V open chamber heads, I have a spare set I would sell reasonable, but they will need to be gone through as they still have stock valves and you should go to modern stainless 1 piece valves as the factory valves are a known weak point on these engines.
Conside oil restrictors or an external line from the galley to the rear sending unit to cure some oiling problems known to exist in the clevelands.
One thing I will preach is get a Cleveland specific thermostat, not what the parts monkeys want to give you
http://www.banzairunnerpantera.com/updates_thermostat.htmI went with a 180 and it keeps my engine running very cool.
Make sure and match intake to head type. a 4v intake will run on a 2v engine, but it will perform poorly and vice versa.
Hooker makes a header for 180 with 1 7/8 pipes and a 3" collector. It is there Comp series, not the super comp.
What is your plan for the ignition system and air cleaner set up?