Sure. I use plastic polish for headlights - NOVUS 2. But other brands are out there as well. I just saw where Meguiar's now has a polish specific for headlight polishing. Its real easy to do if you have a buffer...if not, then you'll have to use your arms and elbows.
What's nice about having plastic polish around is that it will polish lots more than just headlights. I used it to remove the swirls the dealer couldn't get out of my paint. If you get scratches on your cluster gauge plastic window it will remove those as well. Its great for small scatches and scuffs, but hard to remove deep scratches.
Get some. You'll like it.